Thalamic–hippocampal–prefrontal disruption in relapsing–remitting multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Blood-brain barrier disruption in multiple sclerosis.
The blood-brain barrier (BBB) is a complex organization of cerebral endothelial cells (CEC), pericytes and their basal lamina, which are surrounded and supported by astrocytes and perivascular macrophages. Collectively these cells separate and form the compartments of the cerebral vascular space and the cerebral interstitium under normal conditions. Without the BBB, the 'interior milieu' of the...
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Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS). This highlydisabling disorder is characterized by a variable clinical course. MS is a heterogeneous disease with acomplex pathology and significant social and economic impact. MS is associated with dysfunction ofparts of the nervous system which results in a range of signs and symptoms, ...
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Blood-brain barrier (BBB) disruption is one of the hallmarks of multiple sclerosis (MS). It is incompletely understood whether BBB disruption is the initial MS event leading to MS lesion formation or whether it is merely a consequence of cellular infiltration in the central nervous system (CNS). The presence of gadolinium enhancing (Gd+) lesions on serial brain MRI scans is frequently used to e...
متن کاملThalamic–hippocampal–prefrontal disruption in relapsing–remitting multiple sclerosis
BACKGROUND Cortical, thalamic and hippocampal gray matter atrophy in relapsing-remitting MS (RRMS) is associated cognitive deficits. However, the role of interconnecting white matter pathways including the fornix, cingulum, and uncinate fasciculus (UF) is less well studied. OBJECTIVE To assess MS damage to a hippocampal-thalamic-prefrontal network and the relative contributions of its compone...
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ژورنال
عنوان ژورنال: NeuroImage: Clinical
سال: 2015
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2014.12.015